Comparing Cresta and Hyro? Both are Contact Center & CCaaS and Voice & Phone AI tools in the directory, which is why buyers put them on the same shortlist. Below is a side-by-side look at how they price, what they integrate with, and when each is the better fit, so you can pick on the facts rather than either vendor's own sales page.
| Attribute | Cresta | Hyro |
|---|---|---|
| Pricing | Paid · Custom | Paid · Custom |
| Founded | 2017 | 2018 |
| Categories | Agent Assist & Copilots Contact Center & CCaaS QA & Conversation Analytics Voice & Phone AI | AI Agents & Chatbots Contact Center & CCaaS Voice & Phone AI |
| Integrations | Salesforce Five9 Genesys Amazon Connect NICE Avaya | Epic MyChart Salesforce Health Cloud Genesys Cloud Five9 |
Cresta started from a simple observation: in every contact center, a handful of agents dramatically outperform the rest, and everything they do differently is sitting in the call recordings. Founded in 2017 by Zayd Enam, Tim Shi, and Sebastian Thrun, the Stanford professor behind Google X and Udacity, Cresta mines those conversations to learn what the best performers do, then coaches every agent in real time: suggested responses, knowledge, and guidance appearing on screen during live calls and chats.
That real-time layer is still the heart of the product, but the platform now spans the full loop. Conversation intelligence gives leaders visibility into every interaction, automated quality management replaces sampled QA scorecards, a training simulator lets agents rehearse against AI customers, and autonomous virtual agents take the high-volume calls that never needed a human. It plugs into the major contact-center stacks, including Five9, Genesys, Amazon Connect, NICE, and Avaya, so it layers onto what you run rather than replacing it.
Cresta sells to serious operations: United Airlines, Alaska Airlines, Cox Communications, Marriott, and Brinks Home are named customers, and investors including Andreessen Horowitz, Sequoia, and Greylock have backed it to the tune of roughly $276 million, most recently a $125 million Series D in late 2024 that valued the company around $1.6 billion. Pricing is enterprise and quote-based, with no public numbers.
Cresta is the pick when your strategy is making human agents better rather than replacing them, especially in revenue-bearing conversations like sales and retention where a slightly better sentence is worth real money. If you want humans out of the loop entirely, look at the autonomous-agent specialists; if you want your hundred agents performing like your best ten, Cresta was built for exactly that.
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Hyro builds AI agents for healthcare, aimed at the call centers and websites of hospitals and health systems. Its voice and chat agents run over phone, web, SMS, and mobile apps and handle patient facing drudgery: scheduling and rescheduling appointments, prescription refills, MyChart troubleshooting, billing questions, and call routing, with escalation to humans when needed. Deep EHR integration, especially with Epic, is the differentiator, letting agents complete tasks end to end instead of reading FAQs aloud. In June 2026 it launched Care Intelligence, an analytics layer that turns millions of agent conversations into patient access insights for operations teams.
Israel Krush and Rom Cohen founded Hyro in 2018 during their final semester at Cornell Tech, and Weill Cornell Medicine became both first customer and investor. The company now serves around 45 large healthcare organizations, including Intermountain Health, Baptist Health, Hackensack Meridian Health, and Bon Secours Mercy Health. It has raised $95 million in total, most recently a $45 million growth round in October 2025 led by Healthier Capital, the fund of former One Medical CEO Amir Dan Rubin, with Norwest and Define Ventures participating. A May 2026 Five9 partnership cut contact center integration to about an hour.
Hyro does not publish pricing. Contracts are custom, scoped to call volume, channels, and integration depth, and its own 2026 benchmark report frames value in ROI terms, claiming deep EHR integrations unlock over $1 million in returns. Expect an enterprise sales process with security and HIPAA review, not a signup page.
Choose Hyro if you are a health system, especially an Epic shop, drowning in patient access calls, and you want a vendor that lives entirely in healthcare, speaks HIPAA natively, and plugs into your existing contact center stack. If you are outside healthcare it is simply not for you, and small clinics without real call center volume will struggle to justify the enterprise motion.
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