Comparing Five9 and Hyro? Both are Contact Center & CCaaS and Voice & Phone AI tools in the directory, which is why buyers put them on the same shortlist. Below is a side-by-side look at how they price, what they integrate with, and when each is the better fit, so you can pick on the facts rather than either vendor's own sales page.
| Attribute | Five9 | Hyro |
|---|---|---|
| Pricing | Paid · $119/seat/mo | Paid · Custom |
| Founded | 2001 | 2018 |
| Categories | Contact Center & CCaaS Enterprise Voice & Phone AI | AI Agents & Chatbots Contact Center & CCaaS Voice & Phone AI |
| Integrations | Salesforce ServiceNow Microsoft Dynamics 365 Zendesk Oracle Microsoft Teams Zoom RingCentral | Epic MyChart Salesforce Health Cloud Genesys Cloud Five9 |
Five9 is a cloud contact center platform, the kind that runs the whole operation: inbound and outbound voice, chat, email, SMS, and social messaging, plus routing, quality management, and workforce tools. Its Genius AI suite threads through everything, with voice and digital AI Agents that resolve customer conversations on their own, AI Agent Assist that transcribes calls and coaches live reps, and AI Summaries, Insights, and Knowledge doing the after-call cleanup. In 2025 Five9 pushed hard into what it calls Agentic CX, adding an Agentic Engine plus AI Trust and Governance controls.
The company has been at this since 2001, when it started in San Ramon, California, betting that contact centers belonged in the cloud back when they lived in server closets. It went public on NASDAQ in April 2014 at 7 dollars a share under the ticker FIVN. In 2021 Zoom agreed to buy Five9 for roughly 14.7 billion dollars in stock, then shareholders balked and the deal was terminated that September. Longtime CEO Mike Burkland retired, handing the job to Amit Mathradas in February 2026. Today Five9 claims more than 3,000 customers, including Alaska Airlines, PUMA, Omaha Steaks, Wyndham, and Exact Sciences.
Five9 publishes exactly two prices. Digital costs 119 dollars per concurrent seat per month for digital channels only, and Core costs 159 dollars with voice included. The Plus, Pro, and Enterprise bundles are quote only, and everything carries a 50 seat minimum plus usage based charges. Bundled AI covers 3,000 minutes per seat before metered fees kick in, and the serious stuff, AI Agents and virtual agents, is sold as add-ons through sales. Budget accordingly.
Choose Five9 if you run a genuine contact center with 50 or more seats and want voice, digital channels, and AI under one roof from a vendor that will still exist next year. Skip it if you are a small team wanting a simple helpdesk: Zendesk or Intercom will fit better, cost less, and skip the sales calls.
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Hyro builds AI agents for healthcare, aimed at the call centers and websites of hospitals and health systems. Its voice and chat agents run over phone, web, SMS, and mobile apps and handle patient facing drudgery: scheduling and rescheduling appointments, prescription refills, MyChart troubleshooting, billing questions, and call routing, with escalation to humans when needed. Deep EHR integration, especially with Epic, is the differentiator, letting agents complete tasks end to end instead of reading FAQs aloud. In June 2026 it launched Care Intelligence, an analytics layer that turns millions of agent conversations into patient access insights for operations teams.
Israel Krush and Rom Cohen founded Hyro in 2018 during their final semester at Cornell Tech, and Weill Cornell Medicine became both first customer and investor. The company now serves around 45 large healthcare organizations, including Intermountain Health, Baptist Health, Hackensack Meridian Health, and Bon Secours Mercy Health. It has raised $95 million in total, most recently a $45 million growth round in October 2025 led by Healthier Capital, the fund of former One Medical CEO Amir Dan Rubin, with Norwest and Define Ventures participating. A May 2026 Five9 partnership cut contact center integration to about an hour.
Hyro does not publish pricing. Contracts are custom, scoped to call volume, channels, and integration depth, and its own 2026 benchmark report frames value in ROI terms, claiming deep EHR integrations unlock over $1 million in returns. Expect an enterprise sales process with security and HIPAA review, not a signup page.
Choose Hyro if you are a health system, especially an Epic shop, drowning in patient access calls, and you want a vendor that lives entirely in healthcare, speaks HIPAA natively, and plugs into your existing contact center stack. If you are outside healthcare it is simply not for you, and small clinics without real call center volume will struggle to justify the enterprise motion.
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