Comparing Hyro and NICE CXone? Both are Contact Center & CCaaS and Voice & Phone AI tools in the directory, which is why buyers put them on the same shortlist. Below is a side-by-side look at how they price, what they integrate with, and when each is the better fit, so you can pick on the facts rather than either vendor's own sales page.
| Attribute | Hyro | NICE CXone |
|---|---|---|
| Pricing | Paid · Custom | Paid · $110/agent/mo |
| Founded | 2018 | 1986 |
| Categories | AI Agents & Chatbots Contact Center & CCaaS Voice & Phone AI | Contact Center & CCaaS Enterprise Voice & Phone AI |
| Integrations | Epic MyChart Salesforce Health Cloud Genesys Cloud Five9 | Salesforce Microsoft Dynamics Oracle ServiceNow Zendesk Kustomer Pega Snowflake |
Hyro builds AI agents for healthcare, aimed at the call centers and websites of hospitals and health systems. Its voice and chat agents run over phone, web, SMS, and mobile apps and handle patient facing drudgery: scheduling and rescheduling appointments, prescription refills, MyChart troubleshooting, billing questions, and call routing, with escalation to humans when needed. Deep EHR integration, especially with Epic, is the differentiator, letting agents complete tasks end to end instead of reading FAQs aloud. In June 2026 it launched Care Intelligence, an analytics layer that turns millions of agent conversations into patient access insights for operations teams.
Israel Krush and Rom Cohen founded Hyro in 2018 during their final semester at Cornell Tech, and Weill Cornell Medicine became both first customer and investor. The company now serves around 45 large healthcare organizations, including Intermountain Health, Baptist Health, Hackensack Meridian Health, and Bon Secours Mercy Health. It has raised $95 million in total, most recently a $45 million growth round in October 2025 led by Healthier Capital, the fund of former One Medical CEO Amir Dan Rubin, with Norwest and Define Ventures participating. A May 2026 Five9 partnership cut contact center integration to about an hour.
Hyro does not publish pricing. Contracts are custom, scoped to call volume, channels, and integration depth, and its own 2026 benchmark report frames value in ROI terms, claiming deep EHR integrations unlock over $1 million in returns. Expect an enterprise sales process with security and HIPAA review, not a signup page.
Choose Hyro if you are a health system, especially an Epic shop, drowning in patient access calls, and you want a vendor that lives entirely in healthcare, speaks HIPAA natively, and plugs into your existing contact center stack. If you are outside healthcare it is simply not for you, and small clinics without real call center volume will struggle to justify the enterprise motion.
Read the full Hyro listing → · See Hyro alternatives →
NICE CXone is an enterprise cloud contact center platform covering the full span of customer service work: omnichannel routing across voice, chat, email, and social, IVR and self-service AI agents, copilots that assist human agents and supervisors in real time, plus workforce management, quality management, and interaction analytics. The AI layer runs on Enlighten, NICE's family of models trained on billions of customer interactions, and the platform powers more than 25 billion interactions a year.
The company story stretches back to 1986, when NICE was founded in Israel as Neptune Intelligence Computer Engineering. It trades on Nasdaq and the Tel Aviv exchange under the ticker NICE, and spent decades in call recording and analytics before buying cloud contact center pioneer inContact in 2016, the deal that created CXone. In June 2024 it bundled Copilot, Autopilot, and Actions into a rebranded platform called CXone Mpower. In 2025 came a new CEO, Scott Russell, a lowercase rebrand to NiCE, and the roughly 955 million dollar acquisition of German conversational AI firm Cognigy, announced in July and closed in September.
Pricing is refreshingly public for an enterprise vendor. The current page lists five suites billed per agent per month: Omnichannel at 110 dollars, Essential at 135, Core at 169, Complete at 209, and Ultimate at 249 plus 25 cents per session. Industry packages for banking, insurance, healthcare, and retail sit at the top tier. Many AI capabilities are add-ons or consumption based, so a realistic AI-heavy rollout still ends in a custom quote.
Choose NICE if you run a large or regulated contact center and want routing, workforce management, quality, and AI from a single vendor with decades of compliance pedigree. The Cognigy deal also makes it a credible bet for enterprises going all in on agentic AI. Look elsewhere if you run a small support team: the packaging and implementation lift assume hundreds or thousands of seats, and a lighter helpdesk with a bolt-on AI agent will get you live much faster.
Read the full NICE CXone listing → · See NICE CXone alternatives →
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