Comparing Hyro and PolyAI? Both are Contact Center & CCaaS and Voice & Phone AI tools in the directory, which is why buyers put them on the same shortlist. Below is a side-by-side look at how they price, what they integrate with, and when each is the better fit, so you can pick on the facts rather than either vendor's own sales page.
| Attribute | Hyro | PolyAI |
|---|---|---|
| Pricing | Paid · Custom | Per resolution · Custom (per-minute) |
| Founded | 2018 | 2017 |
| Categories | AI Agents & Chatbots Contact Center & CCaaS Voice & Phone AI | Contact Center & CCaaS Enterprise Voice & Phone AI |
| Integrations | Epic MyChart Salesforce Health Cloud Genesys Cloud Five9 | Salesforce HubSpot Zendesk Microsoft Dynamics OpenTable Zapier |
Hyro builds AI agents for healthcare, aimed at the call centers and websites of hospitals and health systems. Its voice and chat agents run over phone, web, SMS, and mobile apps and handle patient facing drudgery: scheduling and rescheduling appointments, prescription refills, MyChart troubleshooting, billing questions, and call routing, with escalation to humans when needed. Deep EHR integration, especially with Epic, is the differentiator, letting agents complete tasks end to end instead of reading FAQs aloud. In June 2026 it launched Care Intelligence, an analytics layer that turns millions of agent conversations into patient access insights for operations teams.
Israel Krush and Rom Cohen founded Hyro in 2018 during their final semester at Cornell Tech, and Weill Cornell Medicine became both first customer and investor. The company now serves around 45 large healthcare organizations, including Intermountain Health, Baptist Health, Hackensack Meridian Health, and Bon Secours Mercy Health. It has raised $95 million in total, most recently a $45 million growth round in October 2025 led by Healthier Capital, the fund of former One Medical CEO Amir Dan Rubin, with Norwest and Define Ventures participating. A May 2026 Five9 partnership cut contact center integration to about an hour.
Hyro does not publish pricing. Contracts are custom, scoped to call volume, channels, and integration depth, and its own 2026 benchmark report frames value in ROI terms, claiming deep EHR integrations unlock over $1 million in returns. Expect an enterprise sales process with security and HIPAA review, not a signup page.
Choose Hyro if you are a health system, especially an Epic shop, drowning in patient access calls, and you want a vendor that lives entirely in healthcare, speaks HIPAA natively, and plugs into your existing contact center stack. If you are outside healthcare it is simply not for you, and small clinics without real call center volume will struggle to justify the enterprise motion.
Read the full Hyro listing → · See Hyro alternatives →
PolyAI answers the phone. While most of this directory started with chat and added voice later, PolyAI has been voice-first since three Cambridge machine-learning PhDs, Nikola Mrkšić, Pei-Hao Su, and Tsung-Hsien Wen, founded it in London in 2017 out of the university's Machine Intelligence Lab. Its agents are known for sounding genuinely human and for surviving the things that break lesser systems: interruptions, accents, background noise, and callers who change their mind mid-sentence. Restaurants, hotels, banks, and utilities use it to answer every call instantly, day and night, with customers like PG&E, UniCredit, Golden Nugget, and Fogo de Chao on the roster.
The platform matured into what the company calls an agentic dialog platform: Agent Studio for building and managing agents without code, a developer kit for deeper work, and Raven, a proprietary conversation model trained on more than a billion enterprise conversations. Compliance boxes (SOC 2, HIPAA, PCI) are ticked, which matters because taking payments and health information over the phone is exactly where voice AI earns its keep.
Investors have noticed the wedge. In December 2025 PolyAI raised an $86 million Series D at a valuation around $750 million, with NVIDIA's venture arm participating, bringing total funding past $200 million. Commercially it bills on usage, priced per minute of conversation, with rates scoped to your call volume rather than published on the site.
Choose PolyAI when the phone is your problem. If most of your support pain is hold music, missed calls, and staffing the night shift, a voice-native specialist will beat a chat-first platform's bolted-on telephony, and PolyAI is one of the most proven voice specialists in the market.
Submit your AI customer support software to get listed alongside these tools and show up in head-to-head comparisons.