Comparing Hyro and Sierra AI? Both are AI Agents & Chatbots and Voice & Phone AI tools in the directory, which is why buyers put them on the same shortlist. Below is a side-by-side look at how they price, what they integrate with, and when each is the better fit, so you can pick on the facts rather than either vendor's own sales page.
| Attribute | Hyro | Sierra AI |
|---|---|---|
| Pricing | Paid · Custom | Per resolution · Custom |
| Founded | 2018 | 2023 |
| Categories | AI Agents & Chatbots Contact Center & CCaaS Voice & Phone AI | AI Agents & Chatbots Enterprise Voice & Phone AI |
| Integrations | Epic MyChart Salesforce Health Cloud Genesys Cloud Five9 | Salesforce Zendesk Shopify Twilio Stripe Snowflake |
Hyro builds AI agents for healthcare, aimed at the call centers and websites of hospitals and health systems. Its voice and chat agents run over phone, web, SMS, and mobile apps and handle patient facing drudgery: scheduling and rescheduling appointments, prescription refills, MyChart troubleshooting, billing questions, and call routing, with escalation to humans when needed. Deep EHR integration, especially with Epic, is the differentiator, letting agents complete tasks end to end instead of reading FAQs aloud. In June 2026 it launched Care Intelligence, an analytics layer that turns millions of agent conversations into patient access insights for operations teams.
Israel Krush and Rom Cohen founded Hyro in 2018 during their final semester at Cornell Tech, and Weill Cornell Medicine became both first customer and investor. The company now serves around 45 large healthcare organizations, including Intermountain Health, Baptist Health, Hackensack Meridian Health, and Bon Secours Mercy Health. It has raised $95 million in total, most recently a $45 million growth round in October 2025 led by Healthier Capital, the fund of former One Medical CEO Amir Dan Rubin, with Norwest and Define Ventures participating. A May 2026 Five9 partnership cut contact center integration to about an hour.
Hyro does not publish pricing. Contracts are custom, scoped to call volume, channels, and integration depth, and its own 2026 benchmark report frames value in ROI terms, claiming deep EHR integrations unlock over $1 million in returns. Expect an enterprise sales process with security and HIPAA review, not a signup page.
Choose Hyro if you are a health system, especially an Epic shop, drowning in patient access calls, and you want a vendor that lives entirely in healthcare, speaks HIPAA natively, and plugs into your existing contact center stack. If you are outside healthcare it is simply not for you, and small clinics without real call center volume will struggle to justify the enterprise motion.
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Sierra builds conversational AI agents for the enterprise, and it arrived with about as much star power as a startup can carry. It was founded in 2023 by Bret Taylor and Clay Bavor, and if those names ring a bell it is because Taylor co-created Google Maps, served as CTO of Facebook and co-CEO of Salesforce, and currently chairs the board of OpenAI, while Bavor spent eighteen years at Google leading its virtual and augmented reality work. Company lore says the whole thing was hatched over a grilled branzino lunch in Palo Alto.
The product lives up to the pedigree. From a single build, Sierra deploys a branded agent across chat, voice, email, SMS, and even ChatGPT, following your policies, adopting your brand's voice, and escalating gracefully when a conversation gets thorny. Its voice agents are a standout: they hold natural, low-latency conversations, read sentiment, and can even take a credit card or ACH payment over the phone in one uninterrupted call, with no clumsy handoff to a separate system.
Under the hood sits Agent OS, a platform for building, testing, and supervising agents, with tooling to run voice simulations and rehearse behavior before anything reaches a real customer. Pricing is outcome-based, tied to conversations or successful resolutions and wrapped in multi-year enterprise contracts, so Sierra is aimed at large brands rather than weekend experimenters. Reported customers include SoFi, Ramp, and Brex, and the company says its agents already serve a meaningful slice of the Fortune 50.
Sierra's fundraising has kept pace with its towering ambition, vaulting the company into the rarefied tier of the most valuable AI startups in barely two years. For enterprises that want polished, on-brand agents across every channel and are willing to invest the time and budget to do it properly, Sierra is a genuine marquee choice.
Read the full Sierra AI listing → · See Sierra AI alternatives →
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