Comparing Hyro and Talkdesk? Both are Contact Center & CCaaS and Voice & Phone AI tools in the directory, which is why buyers put them on the same shortlist. Below is a side-by-side look at how they price, what they integrate with, and when each is the better fit, so you can pick on the facts rather than either vendor's own sales page.
| Attribute | Hyro | Talkdesk |
|---|---|---|
| Pricing | Paid · Custom | Paid · $85/user/mo |
| Founded | 2018 | 2011 |
| Categories | AI Agents & Chatbots Contact Center & CCaaS Voice & Phone AI | Contact Center & CCaaS Enterprise Voice & Phone AI |
| Integrations | Epic MyChart Salesforce Health Cloud Genesys Cloud Five9 | Salesforce Zendesk ServiceNow Microsoft Teams Microsoft Dynamics 365 Slack Zoom Epic |
Hyro builds AI agents for healthcare, aimed at the call centers and websites of hospitals and health systems. Its voice and chat agents run over phone, web, SMS, and mobile apps and handle patient facing drudgery: scheduling and rescheduling appointments, prescription refills, MyChart troubleshooting, billing questions, and call routing, with escalation to humans when needed. Deep EHR integration, especially with Epic, is the differentiator, letting agents complete tasks end to end instead of reading FAQs aloud. In June 2026 it launched Care Intelligence, an analytics layer that turns millions of agent conversations into patient access insights for operations teams.
Israel Krush and Rom Cohen founded Hyro in 2018 during their final semester at Cornell Tech, and Weill Cornell Medicine became both first customer and investor. The company now serves around 45 large healthcare organizations, including Intermountain Health, Baptist Health, Hackensack Meridian Health, and Bon Secours Mercy Health. It has raised $95 million in total, most recently a $45 million growth round in October 2025 led by Healthier Capital, the fund of former One Medical CEO Amir Dan Rubin, with Norwest and Define Ventures participating. A May 2026 Five9 partnership cut contact center integration to about an hour.
Hyro does not publish pricing. Contracts are custom, scoped to call volume, channels, and integration depth, and its own 2026 benchmark report frames value in ROI terms, claiming deep EHR integrations unlock over $1 million in returns. Expect an enterprise sales process with security and HIPAA review, not a signup page.
Choose Hyro if you are a health system, especially an Epic shop, drowning in patient access calls, and you want a vendor that lives entirely in healthcare, speaks HIPAA natively, and plugs into your existing contact center stack. If you are outside healthcare it is simply not for you, and small clinics without real call center volume will struggle to justify the enterprise motion.
Read the full Hyro listing → · See Hyro alternatives →
Talkdesk is a cloud contact center platform (CCaaS) with AI built into nearly every layer. Its Ascend AI platform powers Autopilot, a virtual agent that resolves voice and digital conversations on its own, Copilot, which feeds live human agents answers and next best actions, Navigator for AI-driven routing, and analytics that transcribe and score every interaction. Since late 2024 Talkdesk has been threading agentic AI through the whole portfolio, with Autopilot Agentic going GA in July 2025 and an agentic Copilot following in 2026.
The origin story is genuinely good. In 2011 two Portuguese engineers, Tiago Paiva and Cristina Fonseca, built the first version at a Twilio hackathon, initially chasing a MacBook Air prize. The demo won, 500 Startups wrote a seed check, and Paiva moved to San Francisco. A decade later Talkdesk raised a $230 million Series D at a $10 billion valuation, bringing total funding to roughly $498 million. Customers named on its site and in press coverage include BankUnited, Farfetch, Canon, IBM, Trivago, and Fujitsu.
Pricing is unusually public for enterprise CCaaS. Talkdesk lists Digital Essentials at $85 per user per month, Voice Essentials at $105, Elite at $165, and Industry Experience Clouds, tuned for healthcare, financial services, retail, insurance, and more, at $225. Government pricing is custom, add-ons go through sales, and the pricing page does not spell out whether Autopilot and Copilot are included or cost extra. A free Talkdesk Express trial exists for US and Canadian companies under 50 employees.
Choose Talkdesk if you run a real phone-heavy contact center, want AI from one vendor rather than bolted-on point tools, and like industry packs with compliance workflows baked in. It is a full platform, not a widget. If you only need a helpdesk with a chatbot, or you want per-resolution AI pricing on top of Zendesk or Intercom, lighter options will cost less and deploy faster. Small teams should start with Express.
Read the full Talkdesk listing → · See Talkdesk alternatives →
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